TSG-6 Controls Transcription and Activation of Matrix Metalloproteinase 1 in Conjunctivochalasis

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TSG-6 controls transcription and activation of matrix metalloproteinase 1 in conjunctivochalasis.

PURPOSE To investigate the role of anti-inflammatory TSG-6 in controlling MMP-1 and MMP-3, which have been shown to be upregulated in conjunctivochalasis (CCh). METHODS Immunostaining of TSG-6 was compared between normal and CCh conjunctiva and Tenon's capsule. Second cultures of normal and CCh fibroblasts were transfected with or without TSG-6 siRNA and then with or without the addition of T...

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ژورنال

عنوان ژورنال: Investigative Opthalmology & Visual Science

سال: 2012

ISSN: 1552-5783

DOI: 10.1167/iovs.11-8738